<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rusu, Victor</style></author><author><style face="normal" font="default" size="100%">Hoch, Eitan</style></author><author><style face="normal" font="default" size="100%">Mercader, Josep M</style></author><author><style face="normal" font="default" size="100%">Tenen, Danielle E</style></author><author><style face="normal" font="default" size="100%">Gymrek, Melissa</style></author><author><style face="normal" font="default" size="100%">Hartigan, Christina R</style></author><author><style face="normal" font="default" size="100%">DeRan, Michael</style></author><author><style face="normal" font="default" size="100%">von Grotthuss, Marcin</style></author><author><style face="normal" font="default" size="100%">Fontanillas, Pierre</style></author><author><style face="normal" font="default" size="100%">Spooner, Alexandra</style></author><author><style face="normal" font="default" size="100%">Guzman, Gaelen</style></author><author><style face="normal" font="default" size="100%">Deik, Amy A</style></author><author><style face="normal" font="default" size="100%">Pierce, Kerry A</style></author><author><style face="normal" font="default" size="100%">Dennis, Courtney</style></author><author><style face="normal" font="default" size="100%">Clish, Clary B</style></author><author><style face="normal" font="default" size="100%">Carr, Steven A</style></author><author><style face="normal" font="default" size="100%">Wagner, Bridget K</style></author><author><style face="normal" font="default" size="100%">Schenone, Monica</style></author><author><style face="normal" font="default" size="100%">Ng, Maggie C Y</style></author><author><style face="normal" font="default" size="100%">Chen, Brian H</style></author><author><style face="normal" font="default" size="100%">Centeno-Cruz, Federico</style></author><author><style face="normal" font="default" size="100%">Zerrweck, Carlos</style></author><author><style face="normal" font="default" size="100%">Orozco, Lorena</style></author><author><style face="normal" font="default" size="100%">Altshuler, David M</style></author><author><style face="normal" font="default" size="100%">Schreiber, Stuart L</style></author><author><style face="normal" font="default" size="100%">Florez, Jose C</style></author><author><style face="normal" font="default" size="100%">Jacobs, Suzanne B R</style></author><author><style face="normal" font="default" size="100%">Lander, Eric S</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">MEDIA Consortium</style></author><author><style face="normal" font="default" size="100%">SIGMA T2D Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.</style></title><secondary-title><style face="normal" font="default" size="100%">Cell</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Cell</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basigin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell Membrane</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomes, Human, Pair 17</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Mellitus, Type 2</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Knockdown Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Haplotypes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Heterozygote</style></keyword><keyword><style  face="normal" font="default" size="100%">Histone Code</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Models, Molecular</style></keyword><keyword><style  face="normal" font="default" size="100%">Monocarboxylic Acid Transporters</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2017 Jun 29</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">170</style></volume><pages><style face="normal" font="default" size="100%">199-212.e20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. VIDEO ABSTRACT.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/28666119?dopt=Abstract</style></custom1></record></records></xml>