<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gulsuner, S</style></author><author><style face="normal" font="default" size="100%">Stein, D J</style></author><author><style face="normal" font="default" size="100%">Susser, E S</style></author><author><style face="normal" font="default" size="100%">Sibeko, G</style></author><author><style face="normal" font="default" size="100%">Pretorius, A</style></author><author><style face="normal" font="default" size="100%">Walsh, T</style></author><author><style face="normal" font="default" size="100%">Majara, L</style></author><author><style face="normal" font="default" size="100%">Mndini, M M</style></author><author><style face="normal" font="default" size="100%">Mqulwana, S G</style></author><author><style face="normal" font="default" size="100%">Ntola, O A</style></author><author><style face="normal" font="default" size="100%">Casadei, S</style></author><author><style face="normal" font="default" size="100%">Ngqengelele, L L</style></author><author><style face="normal" font="default" size="100%">Korchina, V</style></author><author><style face="normal" font="default" size="100%">van der Merwe, C</style></author><author><style face="normal" font="default" size="100%">Malan, M</style></author><author><style face="normal" font="default" size="100%">Fader, K M</style></author><author><style face="normal" font="default" size="100%">Feng, M</style></author><author><style face="normal" font="default" size="100%">Willoughby, E</style></author><author><style face="normal" font="default" size="100%">Muzny, D</style></author><author><style face="normal" font="default" size="100%">Baldinger, A</style></author><author><style face="normal" font="default" size="100%">Andrews, H F</style></author><author><style face="normal" font="default" size="100%">Gur, R C</style></author><author><style face="normal" font="default" size="100%">Gibbs, R A</style></author><author><style face="normal" font="default" size="100%">Zingela, Z</style></author><author><style face="normal" font="default" size="100%">Nagdee, M</style></author><author><style face="normal" font="default" size="100%">Ramesar, R S</style></author><author><style face="normal" font="default" size="100%">King, M-C</style></author><author><style face="normal" font="default" size="100%">McClellan, J M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetics of schizophrenia in the South African Xhosa.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Autistic Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Bipolar Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Dopamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">gamma-Aminobutyric Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neural Pathways</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophrenia</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">South Africa</style></keyword><keyword><style  face="normal" font="default" size="100%">Synapses</style></keyword><keyword><style  face="normal" font="default" size="100%">Synaptic Transmission</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 01 31</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">367</style></volume><pages><style face="normal" font="default" size="100%">569-573</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6477</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/32001654?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yin, Jiani</style></author><author><style face="normal" font="default" size="100%">Chun, Chun-An</style></author><author><style face="normal" font="default" size="100%">Zavadenko, Nikolay N</style></author><author><style face="normal" font="default" size="100%">Pechatnikova, Natalia L</style></author><author><style face="normal" font="default" size="100%">Naumova, Oxana Yu</style></author><author><style face="normal" font="default" size="100%">Doddapaneni, Harsha V</style></author><author><style face="normal" font="default" size="100%">Hu, Jianhong</style></author><author><style face="normal" font="default" size="100%">Muzny, Donna M</style></author><author><style face="normal" font="default" size="100%">Schaaf, Christian P</style></author><author><style face="normal" font="default" size="100%">Grigorenko, Elena L</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Next Generation Sequencing of 134 Children with Autism Spectrum Disorder and Regression.</style></title><secondary-title><style face="normal" font="default" size="100%">Genes (Basel)</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Genes (Basel)</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Autism Spectrum Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Child</style></keyword><keyword><style  face="normal" font="default" size="100%">Child, Preschool</style></keyword><keyword><style  face="normal" font="default" size="100%">Cohort Studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease Progression</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene Expression Regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Markers</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Predisposition to Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Throughput Nucleotide Sequencing</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Infant</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 07 25</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Approximately 30% of individuals with autism spectrum disorder (ASD) experience developmental regression, the etiology of which remains largely unknown. We performed a complete literature search and identified 47 genes that had been implicated in such cases. We sequenced these genes in a preselected cohort of 134 individuals with regressive autism. In total, 16 variants in 12 genes with evidence supportive of pathogenicity were identified. They were classified as variants of uncertain significance based on ACMG standards and guidelines. Among these were recurring variants in  and , variants in genes that were linked to syndromic forms of ASD (, , , , , and ), and variants in the form of oligogenic heterozygosity (, , and ).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/32722525?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Collins, Ryan L</style></author><author><style face="normal" font="default" size="100%">Brand, Harrison</style></author><author><style face="normal" font="default" size="100%">Karczewski, Konrad J</style></author><author><style face="normal" font="default" size="100%">Zhao, Xuefang</style></author><author><style face="normal" font="default" size="100%">Alföldi, Jessica</style></author><author><style face="normal" font="default" size="100%">Francioli, Laurent C</style></author><author><style face="normal" font="default" size="100%">Khera, Amit V</style></author><author><style face="normal" font="default" size="100%">Lowther, Chelsea</style></author><author><style face="normal" font="default" size="100%">Gauthier, Laura D</style></author><author><style face="normal" font="default" size="100%">Wang, Harold</style></author><author><style face="normal" font="default" size="100%">Watts, Nicholas A</style></author><author><style face="normal" font="default" size="100%">Solomonson, Matthew</style></author><author><style face="normal" font="default" size="100%">O'Donnell-Luria, Anne</style></author><author><style face="normal" font="default" size="100%">Baumann, Alexander</style></author><author><style face="normal" font="default" size="100%">Munshi, Ruchi</style></author><author><style face="normal" font="default" size="100%">Walker, Mark</style></author><author><style face="normal" font="default" size="100%">Whelan, Christopher W</style></author><author><style face="normal" font="default" size="100%">Huang, Yongqing</style></author><author><style face="normal" font="default" size="100%">Brookings, Ted</style></author><author><style face="normal" font="default" size="100%">Sharpe, Ted</style></author><author><style face="normal" font="default" size="100%">Stone, Matthew R</style></author><author><style face="normal" font="default" size="100%">Valkanas, Elise</style></author><author><style face="normal" font="default" size="100%">Fu, Jack</style></author><author><style face="normal" font="default" size="100%">Tiao, Grace</style></author><author><style face="normal" font="default" size="100%">Laricchia, Kristen M</style></author><author><style face="normal" font="default" size="100%">Ruano-Rubio, Valentin</style></author><author><style face="normal" font="default" size="100%">Stevens, Christine</style></author><author><style face="normal" font="default" size="100%">Gupta, Namrata</style></author><author><style face="normal" font="default" size="100%">Cusick, Caroline</style></author><author><style face="normal" font="default" size="100%">Margolin, Lauren</style></author><author><style face="normal" font="default" size="100%">Taylor, Kent D</style></author><author><style face="normal" font="default" size="100%">Lin, Henry J</style></author><author><style face="normal" font="default" size="100%">Rich, Stephen S</style></author><author><style face="normal" font="default" size="100%">Post, Wendy S</style></author><author><style face="normal" font="default" size="100%">Chen, Yii-Der Ida</style></author><author><style face="normal" font="default" size="100%">Rotter, Jerome I</style></author><author><style face="normal" font="default" size="100%">Nusbaum, Chad</style></author><author><style face="normal" font="default" size="100%">Philippakis, Anthony</style></author><author><style face="normal" font="default" size="100%">Lander, Eric</style></author><author><style face="normal" font="default" size="100%">Gabriel, Stacey</style></author><author><style face="normal" font="default" size="100%">Neale, Benjamin M</style></author><author><style face="normal" font="default" size="100%">Kathiresan, Sekar</style></author><author><style face="normal" font="default" size="100%">Daly, Mark J</style></author><author><style face="normal" font="default" size="100%">Banks, Eric</style></author><author><style face="normal" font="default" size="100%">MacArthur, Daniel G</style></author><author><style face="normal" font="default" size="100%">Talkowski, Michael E</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Genome Aggregation Database Production Team</style></author><author><style face="normal" font="default" size="100%">Genome Aggregation Database Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">A structural variation reference for medical and population genetics.</style></title><secondary-title><style face="normal" font="default" size="100%">Nature</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nature</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Continental Population Groups</style></keyword><keyword><style  face="normal" font="default" size="100%">Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Testing</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetics, Medical</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetics, Population</style></keyword><keyword><style  face="normal" font="default" size="100%">Genome, Human</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotyping Techniques</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Middle Aged</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism, Single Nucleotide</style></keyword><keyword><style  face="normal" font="default" size="100%">Reference Standards</style></keyword><keyword><style  face="normal" font="default" size="100%">Selection, Genetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Whole Genome Sequencing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 05</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">581</style></volume><pages><style face="normal" font="default" size="100%">444-451</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Structural variants (SVs) rearrange large segments of DNA and can have profound consequences in evolution and human disease. As national biobanks, disease-association studies, and clinical genetic testing have grown increasingly reliant on genome sequencing, population references such as the Genome Aggregation Database (gnomAD) have become integral in the interpretation of single-nucleotide variants (SNVs). However, there are no reference maps of SVs from high-coverage genome sequencing comparable to those for SNVs. Here we present a reference of sequence-resolved SVs constructed from 14,891 genomes across diverse global populations (54% non-European) in gnomAD. We discovered a rich and complex landscape of 433,371 SVs, from which we estimate that SVs are responsible for 25-29% of all rare protein-truncating events per genome. We found strong correlations between natural selection against damaging SNVs and rare SVs that disrupt or duplicate protein-coding sequence, which suggests that genes that are highly intolerant to loss-of-function are also sensitive to increased dosage. We also uncovered modest selection against noncoding SVs in cis-regulatory elements, although selection against protein-truncating SVs was stronger than all noncoding effects. Finally, we identified very large (over one megabase), rare SVs in 3.9% of samples, and estimate that 0.13% of individuals may carry an SV that meets the existing criteria for clinically important incidental findings. This SV resource is freely distributed via the gnomAD browser and will have broad utility in population genetics, disease-association studies, and diagnostic screening.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">7809</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/32461652?dopt=Abstract</style></custom1></record></records></xml>