<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gulsuner, S</style></author><author><style face="normal" font="default" size="100%">Stein, D J</style></author><author><style face="normal" font="default" size="100%">Susser, E S</style></author><author><style face="normal" font="default" size="100%">Sibeko, G</style></author><author><style face="normal" font="default" size="100%">Pretorius, A</style></author><author><style face="normal" font="default" size="100%">Walsh, T</style></author><author><style face="normal" font="default" size="100%">Majara, L</style></author><author><style face="normal" font="default" size="100%">Mndini, M M</style></author><author><style face="normal" font="default" size="100%">Mqulwana, S G</style></author><author><style face="normal" font="default" size="100%">Ntola, O A</style></author><author><style face="normal" font="default" size="100%">Casadei, S</style></author><author><style face="normal" font="default" size="100%">Ngqengelele, L L</style></author><author><style face="normal" font="default" size="100%">Korchina, V</style></author><author><style face="normal" font="default" size="100%">van der Merwe, C</style></author><author><style face="normal" font="default" size="100%">Malan, M</style></author><author><style face="normal" font="default" size="100%">Fader, K M</style></author><author><style face="normal" font="default" size="100%">Feng, M</style></author><author><style face="normal" font="default" size="100%">Willoughby, E</style></author><author><style face="normal" font="default" size="100%">Muzny, D</style></author><author><style face="normal" font="default" size="100%">Baldinger, A</style></author><author><style face="normal" font="default" size="100%">Andrews, H F</style></author><author><style face="normal" font="default" size="100%">Gur, R C</style></author><author><style face="normal" font="default" size="100%">Gibbs, R A</style></author><author><style face="normal" font="default" size="100%">Zingela, Z</style></author><author><style face="normal" font="default" size="100%">Nagdee, M</style></author><author><style face="normal" font="default" size="100%">Ramesar, R S</style></author><author><style face="normal" font="default" size="100%">King, M-C</style></author><author><style face="normal" font="default" size="100%">McClellan, J M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetics of schizophrenia in the South African Xhosa.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">Autistic Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Bipolar Disorder</style></keyword><keyword><style  face="normal" font="default" size="100%">Dopamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Female</style></keyword><keyword><style  face="normal" font="default" size="100%">gamma-Aminobutyric Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamine</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Male</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neural Pathways</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophrenia</style></keyword><keyword><style  face="normal" font="default" size="100%">Sex Factors</style></keyword><keyword><style  face="normal" font="default" size="100%">South Africa</style></keyword><keyword><style  face="normal" font="default" size="100%">Synapses</style></keyword><keyword><style  face="normal" font="default" size="100%">Synaptic Transmission</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 01 31</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">367</style></volume><pages><style face="normal" font="default" size="100%">569-573</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Africa, the ancestral home of all modern humans, is the most informative continent for understanding the human genome and its contribution to complex disease. To better understand the genetics of schizophrenia, we studied the illness in the Xhosa population of South Africa, recruiting 909 cases and 917 age-, gender-, and residence-matched controls. Individuals with schizophrenia were significantly more likely than controls to harbor private, severely damaging mutations in genes that are critical to synaptic function, including neural circuitry mediated by the neurotransmitters glutamine, γ-aminobutyric acid, and dopamine. Schizophrenia is genetically highly heterogeneous, involving severe ultrarare mutations in genes that are critical to synaptic plasticity. The depth of genetic variation in Africa revealed this relationship with a moderate sample size and informed our understanding of the genetics of schizophrenia worldwide.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6477</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/32001654?dopt=Abstract</style></custom1></record></records></xml>