<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aldinger, Kimberly A</style></author><author><style face="normal" font="default" size="100%">Timms, Andrew E</style></author><author><style face="normal" font="default" size="100%">Thomson, Zachary</style></author><author><style face="normal" font="default" size="100%">Mirzaa, Ghayda M</style></author><author><style face="normal" font="default" size="100%">Bennett, James T</style></author><author><style face="normal" font="default" size="100%">Rosenberg, Alexander B</style></author><author><style face="normal" font="default" size="100%">Roco, Charles M</style></author><author><style face="normal" font="default" size="100%">Hirano, Matthew</style></author><author><style face="normal" font="default" size="100%">Abidi, Fatima</style></author><author><style face="normal" font="default" size="100%">Haldipur, Parthiv</style></author><author><style face="normal" font="default" size="100%">Cheng, Chi V</style></author><author><style face="normal" font="default" size="100%">Collins, Sarah</style></author><author><style face="normal" font="default" size="100%">Park, Kaylee</style></author><author><style face="normal" font="default" size="100%">Zeiger, Jordan</style></author><author><style face="normal" font="default" size="100%">Overmann, Lynne M</style></author><author><style face="normal" font="default" size="100%">Alkuraya, Fowzan S</style></author><author><style face="normal" font="default" size="100%">Biesecker, Leslie G</style></author><author><style face="normal" font="default" size="100%">Braddock, Stephen R</style></author><author><style face="normal" font="default" size="100%">Cathey, Sara</style></author><author><style face="normal" font="default" size="100%">Cho, Megan T</style></author><author><style face="normal" font="default" size="100%">Chung, Brian H Y</style></author><author><style face="normal" font="default" size="100%">Everman, David B</style></author><author><style face="normal" font="default" size="100%">Zarate, Yuri A</style></author><author><style face="normal" font="default" size="100%">Jones, Julie R</style></author><author><style face="normal" font="default" size="100%">Schwartz, Charles E</style></author><author><style face="normal" font="default" size="100%">Goldstein, Amy</style></author><author><style face="normal" font="default" size="100%">Hopkin, Robert J</style></author><author><style face="normal" font="default" size="100%">Krantz, Ian D</style></author><author><style face="normal" font="default" size="100%">Ladda, Roger L</style></author><author><style face="normal" font="default" size="100%">Leppig, Kathleen A</style></author><author><style face="normal" font="default" size="100%">McGillivray, Barbara C</style></author><author><style face="normal" font="default" size="100%">Sell, Susan</style></author><author><style face="normal" font="default" size="100%">Wusik, Katherine</style></author><author><style face="normal" font="default" size="100%">Gleeson, Joseph G</style></author><author><style face="normal" font="default" size="100%">Nickerson, Deborah A</style></author><author><style face="normal" font="default" size="100%">Bamshad, Michael J</style></author><author><style face="normal" font="default" size="100%">Gerrelli, Dianne</style></author><author><style face="normal" font="default" size="100%">Lisgo, Steven N</style></author><author><style face="normal" font="default" size="100%">Seelig, Georg</style></author><author><style face="normal" font="default" size="100%">Ishak, Gisele E</style></author><author><style face="normal" font="default" size="100%">Barkovich, A James</style></author><author><style face="normal" font="default" size="100%">Curry, Cynthia J</style></author><author><style face="normal" font="default" size="100%">Glass, Ian A</style></author><author><style face="normal" font="default" size="100%">Millen, Kathleen J</style></author><author><style face="normal" font="default" size="100%">Doherty, Dan</style></author><author><style face="normal" font="default" size="100%">Dobyns, William B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Redefining the Etiologic Landscape of Cerebellar Malformations.</style></title><secondary-title><style face="normal" font="default" size="100%">Am J Hum Genet</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Am. J. Hum. Genet.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Sep 05</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">105</style></volume><pages><style face="normal" font="default" size="100%">606-615</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Cerebellar malformations are diverse congenital anomalies frequently associated with developmental disability. Although genetic and prenatal non-genetic causes have been described, no systematic analysis has been performed. Here, we present a large-exome sequencing study of Dandy-Walker malformation (DWM) and cerebellar hypoplasia (CBLH). We performed exome sequencing in 282 individuals from 100 families with DWM or CBLH, and we established a molecular diagnosis in 36 of 100 families, with a significantly higher yield for CBLH (51%) than for DWM (16%). The 41 variants impact 27 neurodevelopmental-disorder-associated genes, thus demonstrating that CBLH and DWM are often features of monogenic neurodevelopmental disorders. Though only seven monogenic causes (19%) were identified in more than one individual, neuroimaging review of 131 additional individuals confirmed cerebellar abnormalities in 23 of 27 genetic disorders (85%). Prenatal risk factors were frequently found among individuals without a genetic diagnosis (30 of 64 individuals [47%]). Single-cell RNA sequencing of prenatal human cerebellar tissue revealed gene enrichment in neuronal and vascular cell types; this suggests that defective vasculogenesis may disrupt cerebellar development. Further, de novo gain-of-function variants in PDGFRB, a tyrosine kinase receptor essential for vascular progenitor signaling, were associated with CBLH, and this discovery links genetic and non-genetic etiologies. Our results suggest that genetic defects impact specific cerebellar cell types and implicate abnormal vascular development as a mechanism for cerebellar malformations. We also confirmed a major contribution for non-genetic prenatal factors in individuals with cerebellar abnormalities, substantially influencing diagnostic evaluation and counseling regarding recurrence risk and prognosis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/31474318?dopt=Abstract</style></custom1></record></records></xml>