<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Posey, Jennifer E</style></author><author><style face="normal" font="default" size="100%">O'Donnell-Luria, Anne H</style></author><author><style face="normal" font="default" size="100%">Chong, Jessica X</style></author><author><style face="normal" font="default" size="100%">Harel, Tamar</style></author><author><style face="normal" font="default" size="100%">Jhangiani, Shalini N</style></author><author><style face="normal" font="default" size="100%">Coban Akdemir, Zeynep H</style></author><author><style face="normal" font="default" size="100%">Buyske, Steven</style></author><author><style face="normal" font="default" size="100%">Pehlivan, Davut</style></author><author><style face="normal" font="default" size="100%">Carvalho, Claudia M B</style></author><author><style face="normal" font="default" size="100%">Baxter, Samantha</style></author><author><style face="normal" font="default" size="100%">Sobreira, Nara</style></author><author><style face="normal" font="default" size="100%">Liu, Pengfei</style></author><author><style face="normal" font="default" size="100%">Wu, Nan</style></author><author><style face="normal" font="default" size="100%">Rosenfeld, Jill A</style></author><author><style face="normal" font="default" size="100%">Kumar, Sushant</style></author><author><style face="normal" font="default" size="100%">Avramopoulos, Dimitri</style></author><author><style face="normal" font="default" size="100%">White, Janson J</style></author><author><style face="normal" font="default" size="100%">Doheny, Kimberly F</style></author><author><style face="normal" font="default" size="100%">Witmer, P Dane</style></author><author><style face="normal" font="default" size="100%">Boehm, Corinne</style></author><author><style face="normal" font="default" size="100%">Sutton, V Reid</style></author><author><style face="normal" font="default" size="100%">Muzny, Donna M</style></author><author><style face="normal" font="default" size="100%">Boerwinkle, Eric</style></author><author><style face="normal" font="default" size="100%">Günel, Murat</style></author><author><style face="normal" font="default" size="100%">Nickerson, Deborah A</style></author><author><style face="normal" font="default" size="100%">Mane, Shrikant</style></author><author><style face="normal" font="default" size="100%">MacArthur, Daniel G</style></author><author><style face="normal" font="default" size="100%">Gibbs, Richard A</style></author><author><style face="normal" font="default" size="100%">Hamosh, Ada</style></author><author><style face="normal" font="default" size="100%">Lifton, Richard P</style></author><author><style face="normal" font="default" size="100%">Matise, Tara C</style></author><author><style face="normal" font="default" size="100%">Rehm, Heidi L</style></author><author><style face="normal" font="default" size="100%">Gerstein, Mark</style></author><author><style face="normal" font="default" size="100%">Bamshad, Michael J</style></author><author><style face="normal" font="default" size="100%">Valle, David</style></author><author><style face="normal" font="default" size="100%">Lupski, James R</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">Centers for Mendelian Genomics</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Insights into genetics, human biology and disease gleaned from family based genomic studies.</style></title><secondary-title><style face="normal" font="default" size="100%">Genet Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Genet. Med.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 04</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">21</style></volume><pages><style face="normal" font="default" size="100%">798-812</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Identifying genes and variants contributing to rare disease phenotypes and Mendelian conditions informs biology and medicine, yet potential phenotypic consequences for variation of &gt;75% of the ~20,000 annotated genes in the human genome are lacking. Technical advances to assess rare variation genome-wide, particularly exome sequencing (ES), enabled establishment in the United States of the National Institutes of Health (NIH)-supported Centers for Mendelian Genomics (CMGs) and have facilitated collaborative studies resulting in novel &quot;disease gene&quot; discoveries. Pedigree-based genomic studies and rare variant analyses in families with suspected Mendelian conditions have led to the elucidation of hundreds of novel disease genes and highlighted the impact of de novo mutational events, somatic variation underlying nononcologic traits, incompletely penetrant alleles, phenotypes with high locus heterogeneity, and multilocus pathogenic variation. Herein, we highlight CMG collaborative discoveries that have contributed to understanding both rare and common diseases and discuss opportunities for future discovery in single-locus Mendelian disorder genomics. Phenotypic annotation of all human genes; development of bioinformatic tools and analytic methods; exploration of non-Mendelian modes of inheritance including reduced penetrance, multilocus variation, and oligogenic inheritance; construction of allelic series at a locus; enhanced data sharing worldwide; and integration with clinical genomics are explored. Realizing the full contribution of rare disease research to functional annotation of the human genome, and further illuminating human biology and health, will lay the foundation for the Precision Medicine Initiative.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30655598?dopt=Abstract</style></custom1></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Connaughton, Dervla M</style></author><author><style face="normal" font="default" size="100%">Kennedy, Claire</style></author><author><style face="normal" font="default" size="100%">Shril, Shirlee</style></author><author><style face="normal" font="default" size="100%">Mann, Nina</style></author><author><style face="normal" font="default" size="100%">Murray, Susan L</style></author><author><style face="normal" font="default" size="100%">Williams, Patrick A</style></author><author><style face="normal" font="default" size="100%">Conlon, Eoin</style></author><author><style face="normal" font="default" size="100%">Nakayama, Makiko</style></author><author><style face="normal" font="default" size="100%">van der Ven, Amelie T</style></author><author><style face="normal" font="default" size="100%">Ityel, Hadas</style></author><author><style face="normal" font="default" size="100%">Kause, Franziska</style></author><author><style face="normal" font="default" size="100%">Kolvenbach, Caroline M</style></author><author><style face="normal" font="default" size="100%">Dai, Rufeng</style></author><author><style face="normal" font="default" size="100%">Vivante, Asaf</style></author><author><style face="normal" font="default" size="100%">Braun, Daniela A</style></author><author><style face="normal" font="default" size="100%">Schneider, Ronen</style></author><author><style face="normal" font="default" size="100%">Kitzler, Thomas M</style></author><author><style face="normal" font="default" size="100%">Moloney, Brona</style></author><author><style face="normal" font="default" size="100%">Moran, Conor P</style></author><author><style face="normal" font="default" size="100%">Smyth, John S</style></author><author><style face="normal" font="default" size="100%">Kennedy, Alan</style></author><author><style face="normal" font="default" size="100%">Benson, Katherine</style></author><author><style face="normal" font="default" size="100%">Stapleton, Caragh</style></author><author><style face="normal" font="default" size="100%">Denton, Mark</style></author><author><style face="normal" font="default" size="100%">Magee, Colm</style></author><author><style face="normal" font="default" size="100%">O'Seaghdha, Conall M</style></author><author><style face="normal" font="default" size="100%">Plant, William D</style></author><author><style face="normal" font="default" size="100%">Griffin, Matthew D</style></author><author><style face="normal" font="default" size="100%">Awan, Atif</style></author><author><style face="normal" font="default" size="100%">Sweeney, Clodagh</style></author><author><style face="normal" font="default" size="100%">Mane, Shrikant M</style></author><author><style face="normal" font="default" size="100%">Lifton, Richard P</style></author><author><style face="normal" font="default" size="100%">Griffin, Brenda</style></author><author><style face="normal" font="default" size="100%">Leavey, Sean</style></author><author><style face="normal" font="default" size="100%">Casserly, Liam</style></author><author><style face="normal" font="default" size="100%">de Freitas, Declan G</style></author><author><style face="normal" font="default" size="100%">Holian, John</style></author><author><style face="normal" font="default" size="100%">Dorman, Anthony</style></author><author><style face="normal" font="default" size="100%">Doyle, Brendan</style></author><author><style face="normal" font="default" size="100%">Lavin, Peter J</style></author><author><style face="normal" font="default" size="100%">Little, Mark A</style></author><author><style face="normal" font="default" size="100%">Conlon, Peter J</style></author><author><style face="normal" font="default" size="100%">Hildebrandt, Friedhelm</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Monogenic causes of chronic kidney disease in adults.</style></title><secondary-title><style face="normal" font="default" size="100%">Kidney Int</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Kidney Int.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Apr</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">95</style></volume><pages><style face="normal" font="default" size="100%">914-928</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Approximately 500 monogenic causes of chronic kidney disease (CKD) have been identified, mainly in pediatric populations. The frequency of monogenic causes among adults with CKD has been less extensively studied. To determine the likelihood of detecting monogenic causes of CKD in adults presenting to nephrology services in Ireland, we conducted whole exome sequencing (WES) in a multi-centre cohort of 114 families including 138 affected individuals with CKD. Affected adults were recruited from 78 families with a positive family history, 16 families with extra-renal features, and 20 families with neither a family history nor extra-renal features. We detected a pathogenic mutation in a known CKD gene in 42 of 114 families (37%). A monogenic cause was identified in 36% of affected families with a positive family history of CKD, 69% of those with extra-renal features, and only 15% of those without a family history or extra-renal features. There was no difference in the rate of genetic diagnosis in individuals with childhood versus adult onset CKD. Among the 42 families in whom a monogenic cause was identified, WES confirmed the clinical diagnosis in 17 (40%), corrected the clinical diagnosis in 9 (22%), and established a diagnosis for the first time in 16 families referred with CKD of unknown etiology (38%). In this multi-centre study of adults with CKD, a molecular genetic diagnosis was established in over one-third of families. In the evolving era of precision medicine, WES may be an important tool to identify the cause of CKD in adults.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30773290?dopt=Abstract</style></custom1></record></records></xml>