<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mak, Angel C Y</style></author><author><style face="normal" font="default" size="100%">White, Marquitta J</style></author><author><style face="normal" font="default" size="100%">Eckalbar, Walter L</style></author><author><style face="normal" font="default" size="100%">Szpiech, Zachary A</style></author><author><style face="normal" font="default" size="100%">Oh, Sam S</style></author><author><style face="normal" font="default" size="100%">Pino-Yanes, Maria</style></author><author><style face="normal" font="default" size="100%">Hu, Donglei</style></author><author><style face="normal" font="default" size="100%">Goddard, Pagé</style></author><author><style face="normal" font="default" size="100%">Huntsman, Scott</style></author><author><style face="normal" font="default" size="100%">Galanter, Joshua</style></author><author><style face="normal" font="default" size="100%">Wu, Ann Chen</style></author><author><style face="normal" font="default" size="100%">Himes, Blanca E</style></author><author><style face="normal" font="default" size="100%">Germer, Soren</style></author><author><style face="normal" font="default" size="100%">Vogel, Julia M</style></author><author><style face="normal" font="default" size="100%">Bunting, Karen L</style></author><author><style face="normal" font="default" size="100%">Eng, Celeste</style></author><author><style face="normal" font="default" size="100%">Salazar, Sandra</style></author><author><style face="normal" font="default" size="100%">Keys, Kevin L</style></author><author><style face="normal" font="default" size="100%">Liberto, Jennifer</style></author><author><style face="normal" font="default" size="100%">Nuckton, Thomas J</style></author><author><style face="normal" font="default" size="100%">Nguyen, Thomas A</style></author><author><style face="normal" font="default" size="100%">Torgerson, Dara G</style></author><author><style face="normal" font="default" size="100%">Kwok, Pui-Yan</style></author><author><style face="normal" font="default" size="100%">Levin, Albert M</style></author><author><style face="normal" font="default" size="100%">Celedón, Juan C</style></author><author><style face="normal" font="default" size="100%">Forno, Erick</style></author><author><style face="normal" font="default" size="100%">Hakonarson, Hakon</style></author><author><style face="normal" font="default" size="100%">Sleiman, Patrick M</style></author><author><style face="normal" font="default" size="100%">Dahlin, Amber</style></author><author><style face="normal" font="default" size="100%">Tantisira, Kelan G</style></author><author><style face="normal" font="default" size="100%">Weiss, Scott T</style></author><author><style face="normal" font="default" size="100%">Serebrisky, Denise</style></author><author><style face="normal" font="default" size="100%">Brigino-Buenaventura, Emerita</style></author><author><style face="normal" font="default" size="100%">Farber, Harold J</style></author><author><style face="normal" font="default" size="100%">Meade, Kelley</style></author><author><style face="normal" font="default" size="100%">Lenoir, Michael A</style></author><author><style face="normal" font="default" size="100%">Avila, Pedro C</style></author><author><style face="normal" font="default" size="100%">Sen, Saunak</style></author><author><style face="normal" font="default" size="100%">Thyne, Shannon M</style></author><author><style face="normal" font="default" size="100%">Rodriguez-Cintron, William</style></author><author><style face="normal" font="default" size="100%">Winkler, Cheryl A</style></author><author><style face="normal" font="default" size="100%">Moreno-Estrada, Andrés</style></author><author><style face="normal" font="default" size="100%">Sandoval, Karla</style></author><author><style face="normal" font="default" size="100%">Rodriguez-Santana, Jose R</style></author><author><style face="normal" font="default" size="100%">Kumar, Rajesh</style></author><author><style face="normal" font="default" size="100%">Williams, L Keoki</style></author><author><style face="normal" font="default" size="100%">Ahituv, Nadav</style></author><author><style face="normal" font="default" size="100%">Ziv, Elad</style></author><author><style face="normal" font="default" size="100%">Seibold, Max A</style></author><author><style face="normal" font="default" size="100%">Darnell, Robert B</style></author><author><style face="normal" font="default" size="100%">Zaitlen, Noah</style></author><author><style face="normal" font="default" size="100%">Hernandez, Ryan D</style></author><author><style face="normal" font="default" size="100%">Burchard, Esteban G</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma.</style></title><secondary-title><style face="normal" font="default" size="100%">Am J Respir Crit Care Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Am. J. Respir. Crit. Care Med.</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2018 Jun 15</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">197</style></volume><pages><style face="normal" font="default" size="100%">1552-1564</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;RATIONALE: &lt;/b&gt;Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;OBJECTIVES: &lt;/b&gt;To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;We performed the first whole-genome sequencing pharmacogenetics study from 1,441 children with asthma from the tails of the BDR distribution to identify genetic association with BDR.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MEASUREMENTS AND MAIN RESULTS: &lt;/b&gt;We identified population-specific and shared genetic variants associated with BDR, including genome-wide significant (P &lt; 3.53 × 10) and suggestive (P &lt; 7.06 × 10) loci near genes previously associated with lung capacity (DNAH5), immunity (NFKB1 and PLCB1), and β-adrenergic signaling (ADAMTS3 and COX18). Functional analyses of the BDR-associated SNP in NFKB1 revealed potential regulatory function in bronchial smooth muscle cells. The SNP is also an expression quantitative trait locus for a neighboring gene, SLC39A8. The lack of other asthma study populations with BDR and whole-genome sequencing data on minority children makes it impossible to perform replication of our rare variant associations. Minority underrepresentation also poses significant challenges to identify age-matched and population-matched cohorts of sufficient sample size for replication of our common variant findings.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS: &lt;/b&gt;The lack of minority data, despite a collaboration of eight universities and 13 individual laboratories, highlights the urgent need for a dedicated national effort to prioritize diversity in research. Our study expands the understanding of pharmacogenetic analyses in racially/ethnically diverse populations and advances the foundation for precision medicine in at-risk and understudied minority populations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">12</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/29509491?dopt=Abstract</style></custom1></record></records></xml>