<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Akçimen, Fulya</style></author><author><style face="normal" font="default" size="100%">Ross, Jay P</style></author><author><style face="normal" font="default" size="100%">Liao, Calwing</style></author><author><style face="normal" font="default" size="100%">Spiegelman, Dan</style></author><author><style face="normal" font="default" size="100%">Dion, Patrick A</style></author><author><style face="normal" font="default" size="100%">Rouleau, Guy A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expanded CAG Repeats in ATXN1, ATXN2, ATXN3, and HTT in the 1000 Genomes Project.</style></title><secondary-title><style face="normal" font="default" size="100%">Mov Disord</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Mov Disord</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alleles</style></keyword><keyword><style  face="normal" font="default" size="100%">Ataxin-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Ataxin-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Ataxin-3</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Huntingtin Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Huntington Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Repressor Proteins</style></keyword><keyword><style  face="normal" font="default" size="100%">Spinocerebellar Ataxias</style></keyword><keyword><style  face="normal" font="default" size="100%">Trinucleotide Repeat Expansion</style></keyword><keyword><style  face="normal" font="default" size="100%">Trinucleotide Repeats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2021 02</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">36</style></volume><pages><style face="normal" font="default" size="100%">514-518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;b&gt;BACKGROUND: &lt;/b&gt;Spinocerebellar ataxia types 1, 2, 3 and Huntington disease are neurodegenerative disorders caused by expanded CAG repeats.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS: &lt;/b&gt;We performed an in-silico analysis of CAG repeats in ATXN1, ATXN2, ATXN3, and HTT using 30× whole-=genome sequencing data of 2504 samples from the 1000 Genomes Project.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS: &lt;/b&gt;Seven HTT-positive, 3 ATXN2-positive, 1 ATXN3-positive, and 6 possibly ATXN1-positive samples were identified. No correlation was found between the repeat sizes of the different genes. The distribution of CAG alleles varied by ethnicity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION: &lt;/b&gt;Our results suggest that there may be asymptomatic small expanded repeats in almost 0.5% of these populations. © 2020 International Parkinson and Movement Disorder Society.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/33159825?dopt=Abstract</style></custom1></record></records></xml>