<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Demanelis, Kathryn</style></author><author><style face="normal" font="default" size="100%">Jasmine, Farzana</style></author><author><style face="normal" font="default" size="100%">Chen, Lin S</style></author><author><style face="normal" font="default" size="100%">Chernoff, Meytal</style></author><author><style face="normal" font="default" size="100%">Tong, Lin</style></author><author><style face="normal" font="default" size="100%">Delgado, Dayana</style></author><author><style face="normal" font="default" size="100%">Zhang, Chenan</style></author><author><style face="normal" font="default" size="100%">Shinkle, Justin</style></author><author><style face="normal" font="default" size="100%">Sabarinathan, Mekala</style></author><author><style face="normal" font="default" size="100%">Lin, Hannah</style></author><author><style face="normal" font="default" size="100%">Ramirez, Eduardo</style></author><author><style face="normal" font="default" size="100%">Oliva, Meritxell</style></author><author><style face="normal" font="default" size="100%">Kim-Hellmuth, Sarah</style></author><author><style face="normal" font="default" size="100%">Stranger, Barbara E</style></author><author><style face="normal" font="default" size="100%">Lai, Tsung-Po</style></author><author><style face="normal" font="default" size="100%">Aviv, Abraham</style></author><author><style face="normal" font="default" size="100%">Ardlie, Kristin G</style></author><author><style face="normal" font="default" size="100%">Aguet, François</style></author><author><style face="normal" font="default" size="100%">Ahsan, Habibul</style></author><author><style face="normal" font="default" size="100%">Doherty, Jennifer A</style></author><author><style face="normal" font="default" size="100%">Kibriya, Muhammad G</style></author><author><style face="normal" font="default" size="100%">Pierce, Brandon L</style></author></authors><translated-authors><author><style face="normal" font="default" size="100%">GTEx Consortium</style></author></translated-authors></contributors><titles><title><style face="normal" font="default" size="100%">Determinants of telomere length across human tissues.</style></title><secondary-title><style face="normal" font="default" size="100%">Science</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Science</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Markers</style></keyword><keyword><style  face="normal" font="default" size="100%">Genetic Variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Humans</style></keyword><keyword><style  face="normal" font="default" size="100%">Organ Specificity</style></keyword><keyword><style  face="normal" font="default" size="100%">Telomere</style></keyword><keyword><style  face="normal" font="default" size="100%">Telomere Homeostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Telomere Shortening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2020 09 11</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">369</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing &gt;20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6509</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/32913074?dopt=Abstract</style></custom1></record></records></xml>