<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zeng, Xue</style></author><author><style face="normal" font="default" size="100%">Hunt, Ava</style></author><author><style face="normal" font="default" size="100%">Jin, Sheng Chih</style></author><author><style face="normal" font="default" size="100%">Duran, Daniel</style></author><author><style face="normal" font="default" size="100%">Gaillard, Jonathan</style></author><author><style face="normal" font="default" size="100%">Kahle, Kristopher T</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease.</style></title><secondary-title><style face="normal" font="default" size="100%">Trends Mol Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Trends Mol Med</style></alt-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2019 Apr</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">25</style></volume><pages><style face="normal" font="default" size="100%">265-286</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Recent whole exome sequencing studies in humans have provided novel insight into the importance of the ephrinB2-EphB4-RASA1 signaling axis in cerebrovascular development, corroborating and extending previous work in model systems. Here, we aim to review the human cerebrovascular phenotypes associated with ephrinB2-EphB4-RASA1 mutations, including those recently discovered in Vein of Galen malformation: the most common and severe brain arteriovenous malformation in neonates. We will also discuss emerging paradigms of the molecular and cellular pathophysiology of disease-causing ephrinB2-EphB4-RASA1 mutations, including the potential role of somatic mosaicism. These observations have potential diagnostic and therapeutic implications for patients with rare congenital cerebrovascular diseases and their families.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><custom1><style face="normal" font="default" size="100%">https://www.ncbi.nlm.nih.gov/pubmed/30819650?dopt=Abstract</style></custom1></record></records></xml>